ABX-1431 hydrochloride ( ABX1431 )

Catalog No. M13179 CAS No. 2043074-64-0

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Product Name

ABX-1431 hydrochloride
Note

Research use only, not for human use.
Brief Description

ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL).
Description

ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL); displays 23-fold selectivity for MGLL versus ABHD6 and CES1c, as well as exquisite selectivity of against other members of the serine hydrolase class; inhibits MGLL activity in rodent brain (ED50=0.5-1.4 mg/kg), increases brain 2-AG concentrations, and suppresses pain behavior in the rat formalin pain model.Pain Phase 1 Clinical
Synonyms

ABX1431
Pathway

Metabolic Enzyme/Protease
Target

MAGL
Recptor

MAGL
Research Area

Neurological Disease
Indication

Pain

CAS Number

2043074-64-0
Formula Weight

543.86
Molecular Formula

C20H23ClF9N3O2
Purity

>98% (HPLC)
Solubility

——
SMILES

C1CCN(C1)C2=C(C=CC(=C2)C(F)(F)F)CN3CCN(CC3)C(=O)OC(C(F)(F)F)C(F)(F)F.Cl
Chemical Name

1,1,1,3,3,3-hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate hydrochloride

1. Cisar JS, et al. J Med Chem. 2018 Aug 1. doi: 10.1021/acs.jmedchem.8b00951.

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